Tetradecylthioacetic acid Powder (2921-20-2) video
Tetradecylthioacetic acid powder Specifications
Tetradecylthioacetic acid powder
Tetradecylthioacetic acid (TTA) is a non-β-oxidizable fatty acid analog, which potently regulates lipid homeostasis.
Here we evaluate the ability of TTA to prevent diet-induced and genetically determined adiposity and insulin resistance.
DMSO: soluble ≥22 mg/mL
What is Tetradecylthioacetic acid powder?
Tetradecylthioacetic acid is a synthetic fatty acid used as a nutritional supplement. TTA acts as a peroxisome proliferator-activated receptor alpha agonist and increases mitochondrial fatty acid oxidation in vitro.
Tetradecylthioacetic acid powder uses?
TTA has been shown to have a number of general health benefits. These benefits include boosting the immune system, promoting healthy cholesterol, working as an anti-inflammatory and improving blood flow.
Tetradecylthioacetic acid powder benefits
What it’ll do for you: “Early studies are suggesting that [TTA] helps to burn fat from the body without the need for exercise,” explains Amy Shapiro, RD and CDN of AWS Nutrition. Often used in conjunction with other supplements (such as sesamin), TTA can help individuals feel full more quickly while the fatty acid decreases overall hunger and burns fat. In addition to regulating fat metabolism, this fatty acid has antioxidant, anti-inflammatory and immunity-enhancing properties. Here, a closer look at the key benefits:
May aid in fat-loss efforts TTA has been found to enhance mitochondrial function and therefore increase the energy level in cells (also known as the metabolism), which further equals an increased fat loss. In 2009, a Norwegian study observed rats on a high-fat diet for seven weeks. Despite eating even more food than usual during the final two weeks, the rats fed TTA gained less body weight than the other rats not getting TTA. This effect has been found independent exercise. “If you exercise, too, it will speed up your fat loss because your body will continue to burn fat at rest and when exercising,” explains Shapiro.
May lower cholesterol Research suggests that TTA activates receptors that are responsible for decreasing the creation of LDL particles (the bad cholesterol). Eighteen healthy men between the ages of 18 and 55 were given doses of TTA for one week—and were studied for an additional week after supplementation stopped. The researchers concluded that TTA reduced the total plasma cholesterol and triacylglycerol levels by 17 percent by increasing the number of mitochondria and by stimulating the oxidation of normal fatty acids. What do Triglycerides matter? Shapiro explains it: “These are fats in the blood so, if TTA helps to increase fat burn, it makes sense that there would also be less fat floating in the blood.”
Boosts insulin sensitivity Due to the mitochondria’s increased activity, the body’s cells use glucose more efficiently with less insulin, which is known to increase fat storage. Accordingly, with less insulin, less fat buildup results
Tetradecylthioacetic acidpowder dosage
TTA is often found in fat-lass products such as LipidFX by SciVation and is also marketed as the headliner ingredient with bonus minerals (TTA with electrolytes!).
Studies have demonstrated that TTA is safe and well tolerated when given once daily for seven consecutive days at doses up to 1000 mg. However, more research is still needed.
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Løvås, K; Røst, TH; Skorve, J; Ulvik, RJ; Gudbrandsen, OA; Bohov, P; Wensaas, AJ; Rustan, AC; et al. (2009). “Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidation”. Diabetes, Obesity & Metabolism. 11 (4): 304–14. doi:10.1111/j.1463-1326.2008.00958.x. PMID19267708.
Bjørndal, B; Grimstad, T; Cacabelos, D; Nylund, K; Aasprong, OG; Omdal, R; Portero-Otin, M; Pamplona, R; Lied, GA; Hausken, Trygve; Berge, Rolf K. (2012). “Tetradecylthioacetic Acid Attenuates Inflammation and Has Antioxidative Potential During Experimental Colitis in Rats”. Digestive Diseases and Sciences. 58 (1): 97–106. doi:10.1007/s10620-012-2321-2. PMID 22855292.
Madsen, L; Guerre-Millo, M; Flindt, EN; Berge, K; Tronstad, KJ; Bergene, E; Sebokova, E; Rustan, AC; et al. (2002). “Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance”. Journal of Lipid Research. 43 (5): 742–50. PMID11971945.
Pettersen, RJ; Salem, M; Skorve, J; Ulvik, RJ; Berge, RK; Nordrehaug, JE (2008). “Pharmacology and safety of tetradecylthioacetic acid (TTA): Phase-1 study”. Journal of Cardiovascular Pharmacology. 51 (4): 410–7. doi:10.1097/FJC.0b013e3181673be0. PMID18427285.