Tetrahydro Curcumin Powder (36062-04-1)

Tetrahydrocurcumin is a beta-diketone that is curcumin in which both of the double bonds have been reduced to single bonds. It has a role as a metabolite. It is a beta-diketone, a polyphenol and a diarylheptanoid. It derives from a curcumin.

Description

 

Tetrahydro Curcumin Powder (36062-04-1) video

Tetrahydro Curcumin powder Specifications

Name: Tetrahydro Curcumin powder
CAS: 36062-04-1
Function: Tetrahydro Curcumin is a major metabolite of Curcumin that has been shown to have protective effects against diabetes and vascular dysfunction via alleviation of oxidative stress.
Application: A major metabolite of Curcumin
Solubility: Soluble in methanol, chloroform, and DMSO.
Storage Temp: Store at -20° C
Color: Yellow powder

 

What is Tetrahydro Curcumin powder?

Tetrahydrocurcumin is a beta-diketone that is curcumin in which both of the double bonds have been reduced to single bonds. It has a role as a metabolite. It is a beta-diketone, a polyphenol and a diarylheptanoid. It derives from a curcumin.

Tetrahydrocurcumin (THC), is a product of bacterial or intestinal metabolism of curcumin (via the bacterial enzyme NADPH-dependent curcumin reductase). In E. coli curcumin is a substrate for the enzyme NADPH-dependent curcumin reductase which catalyzes the metal-independent reduction of curcumin to dihydrocurcumin (DHC) as an intermediate product, followed by further reduction to tetrahydrocurcumin (THC) as an end product. Tetrahydrocurcumin (THC) exhibits many of the same physiologic and pharmacological activities as curcumin and in some systems may exert greater antioxidant activity than curcumin.

Tetrahydro Curcumin powder uses

Tetrahydro Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family and is a natural antioxidant exhibiting a variety of pharmacological activities and therapeutic properties. It has long been used as a traditional medicine and as a preservative and coloring agent in foods.

Tetrahydro Curcumin powder benefits

Tetrahydrocurcuminoids (THC), a colorless hydrogenated product derived from the yellow curcuminoids, (the biologically active principles from the rhizomes of Curcuma longa), function as efficient antioxidant compounds used for skin whitening. The superior antioxidant property of THC, combined with the lack of yellow color, render this product useful in achromatic food and cosmetic applications that currently employ conventional synthetic antioxidants, anti-inflammatory and antioxidant properties, as well as providing UVB protection. It scavenges and prevents the formation of free radicals. It also inhibits tyrosinase, which inhibits the skin from producing melanin. This product is color-free, unlike the brilliant yellow color of other turmeric extracts and can be used in anti-aging, skin lightening, and sun care and after sun care formulations.

THC offer protection to the skin and should be considered for inclusion as functional antioxidants in topical preparations. Tetrahydrocurcuminoids scavenges free radicals that are generated through exposure to ultraviolet radiation, chemicals or other environmental stress factors which age the skin. The efficacy of Curcuminoids and THC is also concentration dependent, with THC being even more effective at lower concentrations. THC also helps to improve the shelf life of topical formulations by inhibiting the autoxidation of fats by offering protection against rancidity of the fat components used in the formulation of cosmetics. The antiinflammatory effects of THC combined with their efficient antioxidant action render them useful as ingredients in anti-aging formulations, skin lightening and brightening products and topical formulations designed to maintain general skin health and integrity.

Tetrahydro Curcumin powder dosage

The dosages of curcumin and tetrahydrocurcumin were determined by our preliminary study: each test diet contained 0.4 % curcumin or tetrahydrocurcumin in a high-fat diet. The dosage in the diet was based on our preliminary cell culture study: low dosage (0.5–1.5 μg/mL) treatment of curcumin and tetrahydrocurcumin lowered tumor necrosis factor-α (TNF-α) expression in lipopolysaccharide (LPS) activated RAW 264.7 cells (mouse leukaemic monocyte/macrophage cell line).

Tetrahydro Curcumin powder for sale(Where to Buy Tetrahydro Curcumin powder )

Our company enjoys long term relationships with our clients because we focus on customer service and providing great products. If you are interested in our product, we are flexible with the customization of orders to suit your specific need and our quick lead time on orders guarantees you’ll have great tasting our product on-time. We also focus on value-added services. We are available for service questions and information to support your business.

We are an professional Green tea extract powder supplier for several years, we supply products with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.

 

References

  • Curcumin Derivative Epigenetically Reactivates Nrf2 Antioxidative Stress Signaling in Mouse Prostate Cancer TRAMP C1 Cells.Li W, Su ZY, Guo Y, Zhang C, Wu R, Gao L, Zheng X, Du ZY, Zhang K, Kong AN.Chem Res Toxicol. 2018 Feb 19;31(2):88-96. doi: 10.1021/acs.chemrestox.7b00248. Epub 2018 Jan 8.
  • Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: a novel curcuminanalog.Zhou T, Ye L, Bai Y, Sun A, Cox B, Liu D, Li Y, Liotta D, Snyder JP, Fu H, Huang B.PLoS One. 2014 Sep 30;9(9):e107876. doi: 10.1371/journal.pone.0107876. eCollection 2014.
  • Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?Minassi A, Sánchez-Duffhues G, Collado JA, Muñoz E, Appendino G.J Nat Prod. 2013 Jun 28;76(6):1105-12. doi: 10.1021/np400148e. Epub 2013 Jun 6.
  • Synthesis and antioxidant, cytotoxicity and antimicrobial activities of novel curcumin mimics.Bandgar BP, Jalde SS, Korbad BL, Patil SA, Chavan HV, Kinkar SN, Adsul LK, Shringare SN, Nile SH.J Enzyme Inhib Med Chem. 2012 Apr;27(2):267-74. doi: 10.3109/14756366.2011.587416. Epub 2011 Jun 16.

 

Additional information

Type

Anti-Aging