Description

 

Pyridoxal-5-phosphate Specifications

Name:	Pyridoxal-5-phosphate
CAS:	54-47-7
Function:	Pyridoxal 5′-Phosphate is the active form of Vitamin B6 that drives approximately 168 vital enzyme processes in our body.
Application:	Among these vital roles P5P facilitates a process known as deamination — which is responsible for converting essential amino acids into non-essential ones.
Formula:	C8H10NO6P
Melting point:	282.2°F (139°C)
storage temp.	−20°C

 

What is Pyridoxal-5-phosphate?

Pyridoxal phosphate, the active form of vitamin B₆, is a coenzyme in a variety of enzymatic reactions. The Enzyme commission has catalogued more than 140 PLP-dependent activities, corresponding to ~4% of all classified activities.

Pyridoxal-5-phosphate uses?

P5P also helps shuttle certain nutrients — such as magnesium — across cellular membranes which helps increase absorption rates. Pyridoxal 5′-Phosphate is a compound vital to our health, yet often found in short supply.

Pyridoxal-5-phosphate benefits

Pyridoxal 5 Phosphate (P5P): Highly Bioavailable Vitamin B6

P5P also helps shuttle certain nutrients — such as magnesium — across cellular membranes which helps increase absorption rates. Pyridoxal 5′-Phosphate is a compound vital to our health, yet often found in short supply.

Pyridoxal-5-phosphatedosage

Applies to the following strengths: 25 mg; 50 mg; 100 mg; 100 mg/mL; pyridoxal 5′-phosphate 50 mg; (as pyridoxal 5′-phosphate)

Usual Adult Dose for:

• Drug Induced Vitamin/Mineral Deficiency
• Dietary Supplement
• Seizures

Usual Pediatric Dose for:

• Dietary Supplement

Additional dosage information:

• Renal Dose Adjustments
• Liver Dose Adjustments
• Dialysis

Usual Adult Dose for Drug Induced Vitamin/Mineral Deficiency

Isoniazid induced deficiencies: 100 mg intramuscularly or intravenously once a day followed by a 30 mg maintenance dose daily

Poisoning caused by ingestion of over 10 grams of isoniazid: Give an equal amount of pyridoxine, starting with 4 grams intravenously followed by 1 gram intramuscularly every 30 minutes

Usual Adult Dose for Dietary Supplement

Injectable:
Dietary deficiency: 10 to 20 mg intramuscularly or intravenously once a day for 3 weeks
-Follow up with an oral multivitamin containing 2 to 5 mg pyridoxine daily for several weeks.
-Correct poor dietary habits; prescribe a well balanced diet.

Recommended dietary allowance of vitamin B6:
18 years, male: 1.3 mg/day
18 years, female: 1.2 mg/day
19 to 50 years (both genders): 1.3 mg/day
51 to 70 years, male: 1.7 mg/day
51 to 70 years, female: 1.5 mg/day
Pregnancy: 1.9 mg/day
Lactation: 2 mg/day

• Usual Adult Dose for Seizures

Injectable:
Vitamin B6 dependency syndrome: Up to 600 mg intramuscularly or intravenously daily, with a daily intake of 30 mg for life

• Usual Pediatric Dose for Dietary Supplement

Adequate intake of vitamin B6:
0 to 6 months: 0.1 mg/day
7 to 12 months: 0.3 mg/day
Estimated adequate intake of vitamin B6:
1 to 3 years: 0.4 mg/day
4 to 8 years: 0.5 mg/day
9 to 13 years: 0.8 mg/day
14 to 18 years, male: 1.1 mg/day
14 to 18 years, female: 1 mg/day

Recommended dietary allowance of vitamin B6:
1 to 3 years: 0.5 mg/day
4 to 8 years: 0.6 mg/day
9 to 13 years: 1 mg/day
14 to 18 years, male: 1.3 mg/day
14 to 18 years, female: 1.2 mg/day

Pyridoxal-5-phosphate for sale(Where to Buy Pyridoxal-5-phosphate)

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References:

• Kozlov ÉI, L’vova MS (1978). “Stability of water-soluble vitamins and coenzymes. Hydrolysis of pyridoxal-5-phosphate in acidic, neutral, and weakly alkaline solutions”. Pharmaceutical Chemistry Journal. 11 (11): 1543–9. doi:10.1007/BF00778244.
• Percudani R, Peracchi A (September 2003). “A genomic overview of pyridoxal-phosphate-dependent enzymes”. EMBO Reports. 4 (9): 850–4. doi:10.1038/sj.embor.embor914. PMC1326353. PMID 12949584.
• Dolphin D, Poulson R, Avramovic O (1986). “Vitamin B6: Pyridoxal Phosphate” (PDF). Coenzymes and Cofactors. 1, Part B. New York: Wiley Interscience. ISBN 978-0471097853.
• Toney MD (January 2005). “Reaction specificity in pyridoxal phosphate enzymes”. Archives of Biochemistry and Biophysics. 433 (1): 279–87. doi:10.1016/j.abb.2004.09.037. PMID 15581583.