Description
Urolithin A Description
- What is Urolithin A?
Urolithin A is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria and is an inducer of mitophagy. Urolithin A shifts mitochondria from CI- to CII-driven respiration, extends lifespan and improves muscle function. It belongs to the class of organic compounds known as benzo-coumarins or dibenzo-α-pyrones. Its precursors – ellagic acids and ellagitannins – are ubiquitous in nature, including edible plants, such as pomegranates, strawberries, raspberries, and walnuts. Since the 2000s, urolithin A has been subject of preliminary studies regarding its possible biological effects.
Urolithin A can improve the quality and function of mitochondria, and increase the strength and endurance of aging muscles. It is the only natural product that has been proven to restart mitochondrial autophagy and reverse muscle aging.
- Urolithin A uses
Urolithin A is intended for use as an ingredient in select foods or for special dietary uses in meal replacement products based on its nutritive activity in supporting general mitochondrial health.
- Urolithin A benefits
Urolithin A is a type of microflora human metabolite which possesses anti-inflammatory and antioxidant properties. Urolithin A is formed by the metabolism of polyphenols found in some nuts and fruits, notably pomegranates.
Urolithin A are associated with various health benefits, including attenuation of inflammatory signaling, anti-cancer effects and repression of lipid accumulation.
Urolithin A can improve mitochondrial and muscle function .
Urolithin A can improves muscle strength and endurance during aging.
- Urolithin A dosage
Urolithins are metabolites produced in the gut following consumption of ellagitannins and ellagic acid rich foods such as pomegranates, nuts and certain berries. Urolithin A (UA) is one of the predominant isoforms of urolithins in humans and has demonstrated compelling biological activities, suggesting potential benefits of direct consumption of UA. However, an evaluation of the safety of direct administration of UA has not yet been published. The ADME study showed that glucuronidated and sulfonated forms of UA are the predominant metabolites following both oral and i.v. administration. The 28-day (0, 0.175, 1.75, and 5.0% UA mixed in diet) and 90-day studies (0, 1.25, 2.5, and 5.0% UA mixed in diet) showed no alterations in clinical parameters, blood chemistry, or hematology, and did not indicate any target organs, or any specific toxic mechanisms. The NOAEL was the highest dose tested, 5% UA by weight in the diet, or 3451 mg/kg bw/day in males and 3826 mg/kg bw/day in females in the 90-day oral study.
Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
- Urolithin A for sale(Where to Buy Urolithin A)
Our company enjoys long term relationships with our clients because we focus on customer service and providing great products. If you are interested in our product, we are flexible with the customization of orders to suit your specific need and our quick lead time on orders guarantees you’ll have great tasting our product on-time. We also focus on value-added services. We are available for service questions and information to support your business.
We are an professional Urolithin A supplier for several years, we supply products with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.
Urolithin A Specifications
| Name: | Urolithin A |
| Chemical Name: | 3,8-Dihydroxybenzo[c]chromen-6-one |
| CAS: | 1143-70-0 |
| Chemical Formula: | C13H8O4 |
| Molecular Weight: | 228.2 |
| Color: | White to off-white solid powder |
| InChi Key: | RIUPLDUFZCXCHM-UHFFFAOYSA-N |
| SMILES Code: | O=C1C2=CC(O)=CC=C2C3=C(O1)C=C(O)C=C3 |
| Function: | Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis. |
| Application: | Urolithin A is a metabolite of ellagitannin; Pharmaceutical Intermediates |
| Solubility: | Soluble in DMSO (3 mg/mL). |
| Storage Temp: | Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shipping Condition: | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
References
[1]. Paller CJ, Pantuck A, Carducci MA. A review of pomegranate in prostate cancer. Prostate Cancer Prostatic Dis. 2017 Apr 25. doi: 10.1038/pcan.2017.19. [Epub ahead of print] Review. PubMed PMID: 28440320.
[2]. Ito H. Metabolites of the ellagitannin geraniin and their antioxidant activities. Planta Med. 2011 Jul;77(11):1110-5. doi: 10.1055/s-0030-1270749. Epub 2011 Feb 3. Review. PubMed PMID: 21294073.
[3]. Zhao W, et al. Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620colorectal cancer cells. Mol Carcinog. 2018 Feb;57(2):193-200.
[4]. Ishimoto H, et al. In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5901-4.
[5]. Qiu Z, et al. In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells. Food Chem Toxicol. 2013 Sep;59:428-37.
[6].Everything You Need To Know: Urolithin A, B and Urolithin A 8-Methyl Ether
