Description
Urolithin B Description
- What is Urolithin B?
Urolithin B is an urolithin, a type of phenolic compounds produced in the human gut after absorption of ellagitannins-containing food such as pomegranate, strawberries, red raspberries, walnuts or oak-aged red wine. Urolithin B is found in the urine in the form of urolithin B glucuronide.
Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass. Urolithin B can also display estrogenic and/or anti-estrogenic activity.
- Urolithin Buses
Urolithin B is an intestinal microbial metabolite of ellagitannis and exhibits potent anti-oxidant and pro-oxidant activies depending on the assay system and conditions. Urolithin B can also display estrogenic and/or anti-estrogenic activity. It has anti-inflammatory and antioxidant effects. Urolithin B is also used be a regulator of skeletal muscle mass.
- Urolithin Bbenefits
Urolithin B is the only compound that can rebuild cells to recycle defective mitochondria. This process occurs naturally in young human bodies, but with age, the body begins to lose its ability to clear dysfunctional mitochondria. , Which can cause sarcoidosis and attenuation of other tissues.
Urolithin B can improve mitochondrial and muscle function .
Urolithin B can improves muscle strength and endurance during aging.
- Urolithin Bdosage
Urolithin B can mitigate muscle damage experienced during intense exercise and protect muscle against stresses induced by a high-fat diet. Clinical research on Urolithin B in mice found that it enhanced myotubes growth and differentiation by increasing protein synthesis. It demonstrated an ability to inhibit the ubiquitin–proteasome pathway (UPP), the principal mechanism for protein catabolism. It also induced muscle hypertrophy and reduced muscle atrophy.
When compared to testosterone, Urolithin B when taken at 15 uM increased androgen receptor activity by 90% while testosterone was only able to accomplish increased receptor activity of 50% at 100uM. This means that it takes a lot less Urolithin B to increase androgen activity more effectively then the higher amount of testosteronewhich increases androgen activity less effectively.
Moreover, most effective 15uM of Urolithin B larger muscle protein synthesis via 96% when in comparison to 100uM of insulin, which larger muscle protein synthesis via most effective 61%. The belief is that it takes a long way much less Urolithin B to extend muscle protein synthesis with a lot upper degree of effectiveness.
This studies show that Urolithin B can inhibit protein catabolism while simultaneously increase protein synthesis, it is a natural ingredient that helps to build lean muscle while preventing muscle breakdown.
- Urolithin Bfor sale (Where to Buy Urolithin B)
Our company enjoys long term relationships with our clients because we focus on customer service and providing great products. If you are interested in our product, we are flexible with the customization of orders to suit your specific need and our quick lead time on orders guarantees you’ll have great tasting our product on-time. We also focus on value-added services. We are available for service questions and information to support your business.
We are an professional Urolithin B supplier for several years, we supply products with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.
Urolithin B Specifications
| Name: | Urolithin B |
| Chemical Name: | 3-Hydroxy-6H-dibenzo[b,d]pyran-6-one |
| CAS: | 1139-83-9 |
| Chemical Formula: | C13H8O3 |
| Molecular Weight: | 212.2 g/mol |
| Color: | White powder |
| InChi Key: | WXUQMTRHPNOXBV-UHFFFAOYSA-N |
| SMILES Code: | O=C1C2=CC=CC=C2C3=CC=C(O)C=C3O1 |
| Function: | Urolithin B can improve mitochondrial and muscle function . Urolithin B can improves muscle strength and endurance during aging. |
| Application: | Urolithin B is an intestinal microbial metabolite of ellagitannis and exhibits potent anti-oxidant and pro-oxidant activies depending on the assay system and conditions. Urolithin B can also display estrogenic and/or anti-estrogenic activity. |
| Solubility: | Easily soluble in N,N-dimethylformamide and dimethylmethylene. Sulfone, slightly soluble in methanol, ethanol, and ethyl acetate |
| Storage Temp: | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Shipping Condition: | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
References
[1]. Kallio, T., et al.: J. Agr. Food Chem., 61, 10720 (2013); Nealmongkol, P., et al.: Tetrahedron, 69, 9277 (2013); Larrosa, M., et al.: J. Agr. Food Chem., 54, 1611 (2006); Bialonska, D., et al.: J. Agr. Food Chem., 57, 10181 (2009)
[2]. Rodriguez J, et al. Urolithin B, a newly identified regulator of skeletal muscle mass. J Cachexia Sarcopenia Muscle. 2017 Aug;8(4):583-597.
[3]. Lee G, et al. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia. Phytomedicine. 2019 Mar 1;55:50-57.
[4]. Bialonska D, Kasimsetty SG, Khan SI, Ferreira D (11 November 2009). “Urolithins, intestinal microbial metabolites of Pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay”. J Agric Food Chem. 57 (21): 10181–6. doi:10.1021/jf9025794. PMID 19824638
[5]. Cerdá, Begoña; Tomás-Barberán, Francisco A.; Espín, Juan Carlos (2005). “Metabolism of Antioxidant and Chemopreventive Ellagitannins from Strawberries, Raspberries, Walnuts, and Oak-Aged Wine in Humans: Identification of Biomarkers and Individual Variability”. Journal of Agricultural and Food Chemistry. 53 (2): 227–235. doi:10.1021/jf049144d. PMID 15656654.
[6].Everything You Need To Know: Urolithin A, B and Urolithin A 8-Methyl Ether
